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腫瘤早篩甲基化標(biāo)準(zhǔn)品
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腫瘤早篩甲基化標(biāo)準(zhǔn)品
遺傳性基因標(biāo)準(zhǔn)品
優(yōu)生優(yōu)育標(biāo)準(zhǔn)品
HLA標(biāo)準(zhǔn)品
數(shù)字PCR
診斷試劑
技術(shù)服務(wù)
新聞中心
關(guān)于我們
聯(lián)系我們
藥靶模型
Drug Target Model
CBP74149
I. Background | |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine stimulating the production of granulocytes and monocytes from bone marrow precursors. GM-CSF had pro-inflammatory functions and is a therapeutic target in autoimmune disease. GM-CSF signals through JAK2/STAT5 and stimulates the expression of STAT5 target genes. |
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II.. Introduction | |
Expressed gene: | hGM-CSF |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | RPMI-1640+10% FBS+100ug/ml hygromycin+2 ng/ml GM-CSF |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Functional(Report Gene) Assay |
III. Representative Data |
Figure 1. Dose Response of Recombinant Human GM-CSF in hGM-CSF Effector Reporter Cells (Clone 10).
Figure 2. Inhibition of hGM-CSF-induced Reporter Activity by hGM-CSF Neutralizing Antibody in hGM-CSF Effector Reporter Cells (Clone 10).