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診斷試劑
腫瘤早篩甲基化標(biāo)準(zhǔn)品
遺傳性基因標(biāo)準(zhǔn)品
優(yōu)生優(yōu)育標(biāo)準(zhǔn)品
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診斷試劑
diagnosis
Introduction | |
Format | Genomic DNA |
Description | PIK3CA E545G is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E545G confers a gain of function on the Pik3ca protein as demonstrated by increased phosphorylation of Akt and transFormation in cell culture (PMID: 17376864, PMID: 29533785). |
Technical Data | |
DNA Change: | c.1634A>G |
AA Change | p.E545G |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 50% |
Transcript | NM_006218 |
Cosmic ID | COSM764 |
Chr position(GRCh37) | chr3:178936092 |
Buffer: | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | Download for COA |
Storage | 2-8°C |
Expiry | 36 months from the date of manufacture |
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